content in diverse areas of basic and translational research including infectious diseases diabetes hypertension stroke HIV-AIDs therapies and gene therapy. the distal nephron which in turn elevates blood pressure. Two related reports by Ochsner’s Dr Akannsha Singh and Dr Richard Re reflect on the role of intracellular angiotensin in blood pressure control and the potential application of cell-penetrating peptide decoys or related xenobiotics to Epothilone B therapeutic blood pressure control. Our colleagues from The University or college of Queensland Australia Drs Maria Nataatmadja and Malcolm West show that aortic aneurysms associated with Marfan syndrome and bicuspid aortic valve malformation express elevated transforming growth factor beta (TGF-β) Epothilone B and Smad (transcription factor) which are related to increased extracellular matrix production and inflammation. They further show that angiotensin AT1-receptor antagonism can inhibit aneurysm progression through the inhibition of TGF-β expression. Lisa Harrison-Bernard and colleagues at the Louisiana Epothilone B State University or college Health Sciences Center study diabetic nephropathy in murine models. In this issue they statement that afferent arterioles of diabetic kidneys exhibit an enhanced vasoconstrictor response to chymase-dependent intrarenal endothelin formation compared to control kidneys. Collectively their studies lead them to propose that intrarenal chymase-dependent endothelin-1 contributes to a decline in function and progression to end-stage renal disease in patients with type 2 diabetes. In other diabetes breakthroughs Dr T. Cooper Woods and D. J. Lightell from your Ochsner Institute for Translational Research (ITR) investigate the part of the mTOR (mammalian target of rapamycin) pathway in vascular decrease. mTOR inhibitors such as rapamycin are effective clinically in inhibiting intimal thickening. The present study shows however that proliferation and intimal thickening of diabetic vasculature may through an insulin-resistance pathway become relatively impervious to mTOR inhibition. In additional reports from Ochsner Dr George Pankey and his team investigate the in vitro synergy of telavancin and rifampin against antibiotic-resistant Enterococcus. HIV-related studies from Tulane University or college School of Medicine further contribute to explanations of how Kaposi sarcoma herpesvirus illness promotes the evasion of apoptosis in endothelial cells and mechanisms by which potent insulin sensitizers may protect against protease inhibitor-mediated endothelial dysfunction during long-term antiretroviral therapy. In additional reports Children’s Hospital New Orleans shares progress on gene therapy for the treatment of neuroendocrine carcinomas using an adenoviral suicide vector. The lead article in our Evaluations and Commentaries section is definitely a delightful review paper within the neurobiology of nerve injury and regeneration (from Ochsner’s very own Dr Wale Sulaiman) with focus on analysis executed in his lab which has upturned the prominent paradigm by demonstrating that the reason why for functional failing following neural damage and regeneration are in fact quite not the same as those formerly recognized. A thrilling review this paper brings us full circle back again to the visitor editorial that targets the need for challenging the set up dogma in research and medicine. Many of the review content in today’s concern reflect energetic collaborations between analysis scientists in the Epothilone B Ochsner ITR and Ochsner clinicians. Included in these are papers over the need for the stromal microenvironment for cancers stem cell destiny (Li and Margolin) the function of tumor necrosis aspect alpha in ischemia-reperfusion damage (Shuh Cohen and co-workers) the contribution of uncontrolled proliferation of follicular T-helper cells to autoimmunity (Zhang et al) and pet models for the Rabbit Polyclonal to PDK1 (phospho-Tyr9). analysis of diabetic nephropathy (Vashistha and Meggs). In various other collaborations Ochsner’s Dr Nossaman in the Anesthesiology Department provides involved in a long-term successful relationship with Dr Kadowitz in the Tulane University College of Medication and in this matter testimonials soluble guanylyl cyclase (sGC nitric oxide receptor) concentrating on brand-new uses for sGC stimulator realtors in perioperative treatment and cardiopulmonary disorders. We close this section with an assessment content from Epothilone B Dr Rajesh Kumar (Tx A&M Health Research Center) over the cardiac function of varied types of the nuclear aspect kappa B transcription aspect particularly because they relate with pathologies. To conclude you can expect our thank you to.