Pneumatosis cystoides intestinalis (PCI) can be an uncommon disease that does

Pneumatosis cystoides intestinalis (PCI) can be an uncommon disease that does not have symptoms and it is rarely connected with intussusception generally. the decrease we believed that cellular cecum could enjoy an important function in the intussusception. Colonoscopy was performed following the decrease and showed multiple elevated lesions in the ascending colon which were similar to cluster of grapes. The CT scan of the next day revealed no recurrence of the intussusception and the patient has not had symptoms of recurrence ever since. Key Words: Pneumatosis cystoides intestinalis Intussusception Mobile cecum Introduction Pneumatosis cystoides intestinalis (PCI) is usually a rare condition characterized by the presence of air within the submucosa and/or subserosa of the intestinal wall [1]. Abdominal Staurosporine Rabbit polyclonal to WAS.The Wiskott-Aldrich syndrome (WAS) is a disorder that results from a monogenic defect that hasbeen mapped to the short arm of the X chromosome. WAS is characterized by thrombocytopenia,eczema, defects in cell-mediated and humoral immunity and a propensity for lymphoproliferativedisease. The gene that is mutated in the syndrome encodes a proline-rich protein of unknownfunction designated WAS protein (WASP). A clue to WASP function came from the observationthat T cells from affected males had an irregular cellular morphology and a disarrayed cytoskeletonsuggesting the involvement of WASP in cytoskeletal organization. Close examination of the WASPsequence revealed a putative Cdc42/Rac interacting domain, homologous with those found inPAK65 and ACK. Subsequent investigation has shown WASP to be a true downstream effector ofCdc42. radiography contrast enema ultrasonography and computed tomography (CT) scan can demonstrate the presence of intramural intestinal gas [2 3 Possible complications with PCI include pneumoperitoneum volvulus intestinal obstruction perforation and intussusception but those are not frequent [2 3 On the other hand intussusception in adult patients is usually caused by malignant tumor and operative treatment is usually often chosen for the therapy of that [4 5 In this report we present an interesting case of intussusception associated with PCI in a young male patient who was successfully treated by enema and manipulative reduction. Case Report A 29-year-old man who complained of abdominal pain for several days frequented our hospital in June 2014. A physical examination revealed tenderness in the right upper stomach. The serum levels of all variables tested Staurosporine were within the normal range including the white blood cell count (5 600 and C-reactive protein level (0.1 mg/dl). He had a past history of Stevens-Johnson syndrome and bronchiectasis. In addition his chest X-ray showed enlarged lungs like chronic obstructive pulmonary disease (COPD) patients. Abdominal CT scan on the same day revealed multiple air-filled cysts along the intestinal wall and a pseudokidney sign in the transverse colon (fig ?(fig1).1). However neither ischemic change in the Staurosporine colonic wall nor ascites could be seen in the CT scan. Then we performed an enema with gastrographin. The enema examination exhibited so-called crab finger sign and multiple elevated translucency in the transverse colon (fig ?(fig2).2). We diagnosed intussusception associated with PCI. The carefully performed enema and manipulative reduction improved the intussusception. After the reduction his abdominal symptom such as right abdominal pain soon disappeared. The subsequently performed colonoscopy revealed a lot of elevated lesions with easy surface shaped like a cluster of grapes in the ascending colon (fig ?(fig3).3). CT scans of the next day did not show the recurrence of intussusception (fig ?(fig4).4). Though he refused to endure hyperbaric air therapy for PCI he hasn’t had symptoms from the recurrence since. Fig. 1 CT check uncovering a pseudokidney indication (still left; arrowheads) and multiple air-filled cysts along the intestinal wall structure (correct; arrowheads). Fig. 2 A crab finger indication and multiple raised translucency (arrowheads) could possibly be observed in the transverse digestive tract (still left). Gastrographin flew in to the ascending digestive tract after the decrease (correct). Fig. 3 Colonoscopy demonstrated many raised lesions with simple surface shaped such as a cluster of grapes in the ascending digestive tract. Fig. 4 CT scans of the very next day did not display the recurrence of intussusception. There have been multiple air-filled cysts along the intestinal wall structure in the ascending digestive tract (arrowhead). Dialogue PCI is certainly a uncommon condition where multiple pneumatocysts develop in the submucosal or subserosa of the tiny or huge intestine [1]. Many the sufferers haven’t Staurosporine any symptoms commonly. Seldom patients may experience the symptoms such as for example diarrhea mucus release rectal constipation and bleeding [6]. Possible complications connected with PCI consist of pneumoperitoneum volvulus intestinal blockage perforation and intussusception [2 3 Lately the amount of the reviews of PCI continues to be increasing due to the wider usage of CT scans and colonoscopy. Nevertheless the cases which were found with intussusception stay extremely rare still. PCI is certainly classified into.