Hypertension and its risk factors have been thoroughly investigated in multiple human population studies, but little is known about Chinese minorities. higher in non-Hans than Hans in males (BMI: 26.543.23 vs. 24.822.77 kgm?2, P<0.001) and ladies (BMI: 26.923.20 vs. 24.193.16 kgm?2, P<0.001) in the same age group, but buy 118506-26-6 not in those <36-years old. Although Han ladies had normal weights or were slightly obese (age >36, BMI=22.25C24.19 kgm?2), non-Han ladies buy 118506-26-6 from your same age group were found to be severely obese (age groups 36C55, BMI=24.94 kgm?2, age groups >56, BMI=26.92 kgm?2). A strong association between increased BMI and hypertension was demonstrated in all ethnic and gender organizations. The prevalence of hypertension in obese (BMI24 kgm?2) and obese (BMI28 kgm?2), aged (36C81), male, and non-Han participants was significantly greater than in slim (BMI <24 kgm?2), young (17C35), woman Hans, after adjusting for these variables inside a multivariate logistic regression analysis (P<0.001). A high prevalence of hypertension in obese and obese seniors non-Han men suggests that BMI, age, sex and race are important risk factors for hypertension with this Chinese human population. Keywords: body mass index, minority, risk element INTRODUCTION Cardiovascular diseases (CVDs) remain the best cause of death in major racial and ethnic groups worldwide.1 Hypertension is one of the most common CVDs and affects particular ethnic organizations disproportionately in China.2 For example, Kazakh people from Xinjiang buy 118506-26-6 Province have more rapid progression of hypertension than Rabbit Polyclonal to POU4F3 Hans from your same area. Inside a survey from the Chinese National Blood Pressure Survey Cooperative Group within the prevalence of hypertension in different ethnic organizations in buy 118506-26-6 China in 1991, Kazakh males had the fifth highest and Kazakh ladies had the highest rates of hypertension among all ethnic groups in China, which was much higher than Hans.2 These observations suggest an important effect of ethnic-associated life styles and genetic factors on hypertension, a fact that is poorly recognized in China. The causes for these disparities are not fully recognized, although we do know that Kazakh populations are generally obese, have different dietary practices from Hans and have poor access to healthcare facilities.3 The paucity of information about the risk factors that affect blood pressure (BP) and the prevalence of hypertension in these minorities hampers the development and implementation of specific CVD-prevention programs. As one of the most frequent risk factors of hypertension, weight problems is definitely defined as an unhealthy excess of body fat. This metabolic disease is related to a number of chronic conditions, such as type 2 diabetes mellitus, hypertension, stroke and coronary artery disease.4 Anthropometric measures, such as body mass index (BMI), are common determinants of obesity in many epidemiological studies. BMI displays total body fat in human population health studies,5 and weight problems is definitely defined according to certain criteria.6 In 2000, the entire world Health Corporation (WHO) proposed a unified worldwide definition of the terms obese and overweight. However, compared with Western populations, Chinese people have a slender build, and `standard’ definitions of weight problems may not apply. Consequently, the WHO lowered BMI ideals to define obese and obese people living in the Asia-Pacific region.7,8 For example, the criteria for defining an individual as overweight (23.0 kgm?2) or obese (25 kgm?2) are lower for Chinese people than for those living in Western countries (25 kgm?2 and 30 kgm?2, respectively).9 Earlier studies showed the prevalence of hypertension, diabetes, dyslipidemia and their risk factors is associated with higher BMI.10 Although these observations were made in Chinese populations to identify individuals at high risk of CVD, to our knowledge, race-specific correlation studies between body fat distribution and CVDs such as hypertension have not been documented. Such as, although it is generally approved that BP differs among Chinese minorities, info on body fat composition or distribution and association with age and gender are lacking. Xinjiang Province is one of the unique buy 118506-26-6 provinces in China where multiple minorities have different lifestyles such as diet differences. Weight problems along with other risk factors among Xinjiang minorities and their association with hypertension prevalence are important, but remain largely unknown. We investigated whether the association of hypertension and the weight problems risk factors, BMI, age, race and gender, differs between Han and non-Han Chinese minorities with this province, and whether age, race and gender influence this correlation. METHODS Study human population This study was a medical survey-based study performed from March 2007 to February 2009 in the city of Urumqi, Xinjiang, China. A total of 9913 annual physical exam individuals from three hospitals, including the Urumqi 1st People Hospital, Xinjiang Petroleum College Hospital, and Xinjiang Market College Hospital, were.